(ST. JOSEPH, Mo.) At halftime, North Andrew led Bishop LeBlond, 28-12, and in the second half, the Cardinals tacked on 32 points.
The Cardinals held LeBlond to eight second-half points.
North Andrew improves to 2-0 with the 60-20 win and the Golden Eagles fall to 0-2.
The Cardinals will travel to Pattonsburg next week.
Bishop LeBlond travels to Doniphan West Friday.